Ciliary beating patterns map onto a low-dimensional behavioural space
نویسندگان
چکیده
Abstract Biological systems are robust to perturbations at both the genetic and environmental levels, although these same can elicit variation in behaviour. The interplay between functional robustness behavioural variability is exemplified organellar level by beating of cilia flagella. Cilia motile despite wide diversity within species, differences intracellular concentrations ATP calcium, considerable environment fluctuations temperature viscosity. At time, result a variety spatio-temporal patterns that span rich space. To investigate this space we analysed dynamics isolated from unicellular algae Chlamydomonas reinhardtii under many different conditions. We found that, large changes beat frequency amplitude, waveform shapes low-dimensional sense two features account for 80% observed variation. geometry accords with predictions simple mechanochemical model low-viscosity regime. This allowed us associate shape only curvature response coefficients dynein motors.
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ژورنال
عنوان ژورنال: Nature Physics
سال: 2022
ISSN: ['1745-2473', '1745-2481']
DOI: https://doi.org/10.1038/s41567-021-01446-2